10/7/2023 0 Comments Valium poisoning antidoteConcentrations of diazepam and its metabolites were measured with LC-MS. Male Wistar rats were divided in four main groups and treated as follows: group I-with increasing doses of diazepam in order to produce the highest level of sedation and motor activity impairment group II-diazepam + different doses of flumazenil group III-diazepam + different doses of theophylline group IV-diazepam + combined application of theophylline and flumazenil. The aim of the present study was to examine the effects of combined application of theophylline and flumazenil on sedation and impaired motor function activity in acute diazepam poisoning in. The majority of symptoms and signs of acute diazepam poisoning are the consequence of its sedative effect on the CNS affecting selectively poli-synaptic routes by stimulating inhibitory action of GABA.
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